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TED-Ed

How do you know if you have a virus? - Cella Wright

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A new virus emerges and spreads like wildfire. In order to contain it, researchers must first collect data about who’s been infected. Two main viral testing techniques are critical: one tells you if you have the virus and the other shows if you’ve already had it. So, how exactly do these tests work? Cella Wright explores the science of PCR tests and immunoassays.

Additional Resources for you to Explore

Scientists and researchers are currently using two main viral testing techniques. These tests work differently and can determine which individuals are currently or have previously been infected by a specific virus. Can these viral testing results potentially be used to create a treatment?

The PCR technique was discovered by Kary Mullis in the mid 1980’s. As a result of his revolutionary work to create massive quantities of genetic material, such as DNA, he received the 1993 Nobel Prize in chemistry. Many scientists have embraced this simple technology which has been adapted to suit many other applications related to health and science.

The first immunoassay was described by Solomon Berson and Rosalyn Yalow in 1959. They received the Nobel Prize in Medicine in 1977 due to this work. Since then, the work with immunoassays has changed and evolved significantly. Immunoassays play a vital role in many clinics and laboratories, the pharmaceutical industry, environmental monitoring, security, and food testing. To learn about the history and future applications of immunoassays check out this Pub Med article.

Both of these tests are currently being used to get genetic information from new and past viruses and bacterial diseases. To read more about how reliable these genetic tests are, check out this article from the National Public Radio (NPR). Click on this article to learn more about COVID-19 viral testing and how it has been used in the past.


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Meet The Creators

Educator
Cella Wright
Director
Luísa Holanda
Narrator
Bethany Cutmore-Scott
Storyboard Artist
Luísa Holanda
Art Director
Luísa Holanda
Compositor
Gabriel Maia
Animator
Maurício Canterle, Murilo Jardim, Felipe Urbanetto
Music
Gabriel Maia
Sound Designer
Gabriel Maia
Hype Producer
Taíla Soliman
Hype Executive Producer
Gabriel Garcia
Director of Production
Gerta Xhelo
Editorial Producer
Alex Rosenthal
Producer
Bethany Cutmore-Scott
Associate Editorial Producer
Cella Wright
Fact-Checker
Joseph Isaac
Science Consultant
Dr. Jim Huggett, Dr. Daniel Stadlbauer
Special Thanks
Alejandra Guzman, The Genetics Society , Laurence Hurst

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