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The missing plague that could have changed history

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When European colonizers came to American shores, the plague they brought with them killed almost 90% of the indigenous population. But why was there no existing plague in the "New World" that affected Europeans?

CGP Grey explains in this video about the missing "Americapox."

Plagues come from animals but so rarely that in order for a plague to be created, the odds of infection have to be heightened. What can raise the odds of infection?

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