The race to sequence the human genome - Tien Nguyen
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In 1990, The Human Genome Project proposed to sequence the entire human genome over 15 years with $3 billion of public funds. Then, seven years before its scheduled completion, a private company called Celera announced that they could accomplish the same goal in just three years at a fraction of the cost. Tien Nguyen details the history of this race to sequence the human genome.
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1 Open Discussion
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The Human Genome Project was a massive undertaking that began as an idea put forward by prominent scientists in the 1980s. For a complete timeline of the Project from start to finish, click here. The DNA database to which the Human Genome Project was uploading their sequenced data is still freely available online and can be found here.
Fred Sanger won the 1980 Nobel Prize in Chemistry for his contribution to the Sanger method, which was used by both the Human Genome Project and Celera. This sequencing technique involves making many copies of DNA in a test tube. Each copy is one letter longer than the last and is capped by a fluorescently labeled base: an A, T, G, or C. Then scientists, or robots, can sort the DNA chains by size and use the colors to read out the strand’s genetic code. You can find an excellent animated video describing the Sanger method here. This TED-Ed lesson also addresses the sequencing of the human genome: How to sequence the human genome. For more on DNA itself, watch these TED Ed lessons: The twisting tale of DNA and How I discovered DNA.
In 2001, both Celera and the Human Genome Project published their initial findings in the journals Science
and Nature, respectively. The Human Genome Project ended their article with a quote by T.S. Eliot: “We shall not cease from exploration. And the end of all our exploring will be to arrive where we started, and know the place for the first time.”
This video was created with the support of the U.S. Office of Research Integrity: http://ori.hhs.gov.
Fred Sanger won the 1980 Nobel Prize in Chemistry for his contribution to the Sanger method, which was used by both the Human Genome Project and Celera. This sequencing technique involves making many copies of DNA in a test tube. Each copy is one letter longer than the last and is capped by a fluorescently labeled base: an A, T, G, or C. Then scientists, or robots, can sort the DNA chains by size and use the colors to read out the strand’s genetic code. You can find an excellent animated video describing the Sanger method here. This TED-Ed lesson also addresses the sequencing of the human genome: How to sequence the human genome. For more on DNA itself, watch these TED Ed lessons: The twisting tale of DNA and How I discovered DNA.
In 2001, both Celera and the Human Genome Project published their initial findings in the journals Science
and Nature, respectively. The Human Genome Project ended their article with a quote by T.S. Eliot: “We shall not cease from exploration. And the end of all our exploring will be to arrive where we started, and know the place for the first time.”
This video was created with the support of the U.S. Office of Research Integrity: http://ori.hhs.gov.
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Meet The Creators
- Educator Tien Nguyen
- Director Barak Drori
- Artist Yossi Gavan
- Producer Michal Boico
- Collaborator Office of Research Integrity
- Narrator Addison Anderson
