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A brief history of antidepressants - Neil R. Jeyasingam

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In the 1950s, the discovery of two new drugs sparked what would become a multi-billion dollar market for antidepressants. Neither drug was intended to treat depression at all— many doctors and scientists believed psychotherapy was the only approach to treatment. Neil R. Jeyasingam details the decades-long journey that followed and how it revolutionized our understanding of depression.

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Meet The Creators

  • Educator Neil R. Jeyasingam
  • Director Skirmanta Jakaite
  • Narrator Addison Anderson
  • Art Director Skirmanta Jakaite
  • Animator Skirmanta Jakaite
  • Storyboard Artist Skirmanta Jakaite
  • Compositor Skirmanta Jakaite
  • Composer Salil Bhayani
  • Sound Designer Spencer Ward, cAMP Studio
  • Director of Production Gerta Xhelo
  • Editorial Director Alex Rosenthal
  • Producer Bethany Cutmore-Scott
  • Editorial Producer Elizabeth Cox
  • Production Coordinator Abdallah Ewis
  • Script Editor Emma Bryce
  • Fact-Checker Eden Girma
  • See more
Additional Resources for you to Explore
The brain has been called the final frontier in medical research, and there have been incredible developments in the last fifty years. Serotonin isn’t the only neurotransmitter that has been identified as the most likely target for medication development. Medical research has identified other neurotransmitters and potential targets of action to treat depression. One of those neurotransmitters is Noradrenaline, which can be used to treat severe depression in patients. Learning about various neurotransmitters in the brain helps us to find causes of other mental illnesses in addition to depression. For instance, dopamine is another neurotransmitter and it’s believed that an overactive dopamine system can cause schizophrenia.
Avatar for Sazia Afrin
Lesson Creator
New York, New York, United States
There are many new medication treatments for depression. But there are also many different talking therapies for depression. How do doctors know which treatments to choose for which person?

12/11/2020
Avatar for Cássio Giovanni
Cássio Giovanni • LESSON IN PROGRESS

Doctors rely on studies made by researchers. Typically they will try first the medication that have fewer side effects and if it don't work, try the next one which have just a bit more side effects. On talking therapies we have studies pointing "The therapy A works better than the therapy B for disease X", so we recommend the therapy A.

Sorry any mistakes, my English is a work in progress.

03/18/2021
Avatar for Acy Brown
Acy Brown • COMPLETED LESSON

One way that doctors could identify which treatment a person needs is by trying therapy first, because that has no side effects, and if that doesn't work, the doctors can try antidepressants.

04/19/2021
Avatar for Nandini Giri
Nandini Giri • COMPLETED LESSON

I think doctors would probably first analyse the reason why the patient is feeling depressed, and then based on the reason and the severity of depression they would decide what treatments to use for that patient.

04/21/2021

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About TED-Ed Animations

TED-Ed Animations feature the words and ideas of educators brought to life by professional animators. Are you an educator or animator interested in creating a TED-Ed Animation? Nominate yourself here »

Meet The Creators

  • Educator Neil R. Jeyasingam
  • Director Skirmanta Jakaite
  • Narrator Addison Anderson
  • Art Director Skirmanta Jakaite
  • Animator Skirmanta Jakaite
  • Storyboard Artist Skirmanta Jakaite
  • Compositor Skirmanta Jakaite
  • Composer Salil Bhayani
  • Sound Designer Spencer Ward, cAMP Studio
  • Director of Production Gerta Xhelo
  • Editorial Director Alex Rosenthal
  • Producer Bethany Cutmore-Scott
  • Editorial Producer Elizabeth Cox
  • Production Coordinator Abdallah Ewis
  • Script Editor Emma Bryce
  • Fact-Checker Eden Girma
  • See more

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